What is IVIG?
IVIG refers to Gamma Globulin which is the chemical portion of blood that contains immunoglobulins or antibodies. They are produced by Plasma Cells and are an important part in the Immune Response. There are five different classes of ImmunoGlobulins: IgG, IgA, IgM, IgD, and IgE.
Gamma globulin has immunomodulatory, and immunoprotective properties, that have led to clinical trials in a wide range of non-infectious, immune-mediated diseases. The exact mechanism of action in Multiple Sclerosis is unknown.
IVIG Indications & Clinical Benefits
Several European Studies published within the last 3 years have confirmed the benefits of IVIG in those patients with clinically definite relapsing-remitting Multiple Sclerosis (defined by Poser, et al in 1983). These studies demonstrated a reduction in the acute relapse rate and the number of contrast-enhanced lesions on monthly MRI scans.
Most importantly, the IVIG treated patients spent significantly more time in an improved or stable neurologic status as compared to the placebo groups, suggesting a better quality of life for the IVIG patients during remission.
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